What size should you make your layout for a web site? Is there one layout that will fit all monitor sizes?

The basic width of a layout determines a lot of the internal layout sizes for panes, modules, images, and internal content.  More...

When it comes to designing layout for on-line content, what size is the right size?  How does one design for multiple screen sizes without spending duplicate effort on multiple designs. The answer depends on what size windows users are using to access the site.  For me, creating a variable fixed width design based on both 960 pixels (large) or 700 pixels (medium) helps minimize duplication of design effort. More...